BlackThorn Therapeutics is dedicated to improving the lives of people with neurobehavioral disorders, such as depression, schizophrenia and autism, through the discovery and development of novel, targeted therapeutic agents. BlackThorn applies data-driven approaches (INFORM™) to create an understanding of the core underlying pathophysiology of neurobehavioral disorders and uses these insights to generate objective neuromarkers that support target identification and localization, patient stratification and objective trial endpoints. We are committed to fostering our chemical expertise and applying it to the successful progression of projects at various stages in the drug discovery and development process.
Apply your synthetic and medicinal chemistry skills and put them into practice alongside the expert chemists on our small but growing team. Your responsibilities will include the preparation (synthetic organic, microwave, and array-style chemistry), purification (normal and reversed phase, automated flash chromatography), and characterization (HPLC, LCMS, NMR) of small molecule, CNS targeted, focused libraries. You will contribute to the evaluation of biological data and participate in an iterative cycle of “design and synthesize,” using state of the art software to optimize molecular properties within our chemical space.
Who You Are
You have working knowledge of and a passion for organic synthesis, as evidenced by a successful laboratory track record of chemical troubleshooting. You are committed to learning and understanding the CNS therapeutic area and physicochemical space. You are eager to contribute to the CNS pharmaceutical drug development process by working collaboratively amongst your Department of Medicinal Chemistry teammates. You enjoy working with a “Start-Up” mentality, nimbly reprioritizing and meeting the demands of a fast-paced environment. A successful candidate will have a demonstrable record of laboratory safety and efficiency, of successful problem solving and risk minimization. Additionally, she or he will be able to use modern chemical hardware / software (ChemDraw, ELN, Analytical, etc…) and searching tools (Scifinder, etc…). You will be able to work independently, and report results both in an ELN format and in Chemistry Team meeting discussions. You have a degree in Organic Chemistry (B.S. or M.S., ACS certification preferred).